12 weeks before fully effective but obliterated my cystic acne. if you have less severe acne you can get adapalene 0.1% (differin gel) without a prescription. do some research first of course but this stuff changed the game for me. apply before bed every night and follow up with a moisturizer if necessary. note that some people experience a purge where their acne gets worse before it gets better because the cream works by increasing the rate of cell turnover, so whatever acne is lying latent under your top layer of skin will get pushed to the surface. if it’s not clear, i have a long history of acne problems. hmu if u need more hot tips