Hugely creative comedy talk show that aired on public access in New York. You might know Gethard from the Beautiful/Anonymous podcast these days or his HBO special, but back then he was an improviser who had improvisers doing bits on a late night talk show. I linked to a good starter episode - you'll know within 5 minutes if it's for you.
Featuring: a live band, live call-ins, random people added to the cast, a different musical guest every show, a human fish, a studio audience of superfans, a variety of topics like Loser is the New Nerd, How do Girls Work, The Genuine Sadness Episode, Turtle Birthday and many more.
It was my PI back when it aired every Wednesday.